منابع مشابه
Reliability of the comet assay in cryopreserved human sperm.
BACKGROUND Although the comet assay has potential value for measuring DNA damage in large epidemiological human sperm studies, it is impractical to perform the assay daily on fresh semen samples. Therefore, before its use in epidemiological studies, the reliability of the comet assay in measuring DNA damage in cryopreserved sperm should be compared with that in fresh human sperm. METHODS Seme...
متن کاملReliability of mutagen sensitivity assay: an inter-laboratory comparison.
Mutagen sensitivity is regarded as a genetic susceptibility phenotype for various cancers; it is cytogenetically based and probably involves a number of genes from different DNA repair pathways. This assay has been used in a number of laboratories in the field of epidemiology, where it has been investigated and appears to be a useful susceptibility biomarker for epidemiological studies assessin...
متن کاملRecommendations for increasing alkaline comet assay reliability in plants.
In plants, an increasing interest for the comet assay was shown in the last decade. This versatile technique appears to be promising to detect the genotoxic effect of pollutants and to monitor the environment. However, the lack of a standardised protocol and the low throughput of the assay limit its use in plants. The aims of this paper are to identify key factors affecting comet assay performa...
متن کاملThe Nijmegen modification of the Bethesda assay for factor VIII:C inhibitors: improved specificity and reliability.
Antibodies against factor VIII coagulant activity can appear in haemophiliacs who are treated with factor VIII preparations but also spontaneously in non-haemophiliacs. The Bethesda assay is the most commonly used method to detect these antibodies, but it lacks specificity especially in the lower range resulting in unreliable data. Two modifications are proposed and tested to resolve the imperf...
متن کاملUtilization of assay performance characteristics to estimate hemoglobin A1c result reliability.
BACKGROUND Allowable total error (TE(a)) goals for hemoglobin (Hb) A(1c) require minimal assay imprecision and bias and implementation of a robust QC monitoring program. Here, we compare the combined influence on the risk of reporting unreliable results of TE(a) goals, a routine QC practice, and assay performance characteristics of 6 Hb A(1c) instruments across 4 academic medical centers. MET...
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ژورنال
عنوان ژورنال: American Journal of Health-System Pharmacy
سال: 1998
ISSN: 1079-2082,1535-2900
DOI: 10.1093/ajhp/55.5.491